Colon Cruises to South America 2025/2026
Save up to 80% on Colon Cruises to South America 2025/2026
As a large-scale seller of Colon Cruises to South America 2025/2026, we are able to offer you unbeatable prices and unparalleled value. With cruise line volume buys plus our low everyday prices you can save up to 80% versus the brochure price! Once you have found the discounted Colon cruise of your choice, please call our cruise consultants to book your vacation and save money with our first-rate personalized service! Book your Colon cruise today with AffordableTours.com, your discounted cruise headquarters.
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- Choose from 1000+ Colon Cruises
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| Sail Date | Cruise Line | Ship | Destination | Departs | Length | Price | You Save | Discounts | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
 | 12 night Caribbean (Colón to Fort-de-France) | Mar 15, 2025 | Ponant | Le Bellot | Colon | Fort-De-France | 12 Nights | Bonaire | Cartagena | Colón | Fort-de-France | Les Saintes | Pigeon Island Beach | San Blas Islands | Santa Marta | Soufrière | Union Island | $9,200 Up To $1000 Onboard Credit | Balcony! | View Itinerary | Get FREE Quote |
100 reviews  | 7 Night Southern Caribbean Cruise | Oct 11, 2025 | Royal Caribbean | Serenade of the Seas | Colon | Colon | 7 Nights | Cartagena - Colombia | Colon - Panama | Oranjestad - Aruba | Willemstad - Curacao | $988 Up To $150 Onboard Credit | Onboard Credit! | View Itinerary | Get FREE Quote |
100 reviews | 7 Night Southern Caribbean Cruise | Oct 18, 2025 | Royal Caribbean | Serenade of the Seas | Colon | Colon | 7 Nights | Cartagena - Colombia | Colon - Panama | Oranjestad - Aruba | Willemstad - Curacao | $1,029 Up To $150 Onboard Credit | View Itinerary | Get FREE Quote | |
100 reviews | 7 Night Southern Caribbean Cruise | Oct 25, 2025 | Royal Caribbean | Serenade of the Seas | Colon | Colon | 7 Nights | Cartagena - Colombia | Colon - Panama | Oranjestad - Aruba | Willemstad - Curacao | $939 Up To $150 Onboard Credit | Onboard Credit! | View Itinerary | Get FREE Quote |
100 reviews | 7 Night Southern Caribbean Cruise | Nov 01, 2025 | Royal Caribbean | Serenade of the Seas | Colon | Colon | 7 Nights | Cartagena - Colombia | Colon - Panama | Oranjestad - Aruba | Willemstad - Curacao | $1,089 Up To $150 Onboard Credit | Onboard Credit! | View Itinerary | Get FREE Quote |
100 reviews | 7 Night Southern Caribbean Cruise | Nov 08, 2025 | Royal Caribbean | Serenade of the Seas | Colon | Colon | 7 Nights | Cartagena - Colombia | Colon - Panama | Kralendijk - Bonaire | Willemstad - Curacao | $935 Up To $150 Onboard Credit | View Itinerary | Get FREE Quote | |
100 reviews | 7 Night Southern Caribbean Cruise | Nov 15, 2025 | Royal Caribbean | Serenade of the Seas | Colon | Colon | 7 Nights | Cartagena - Colombia | Colon - Panama | Oranjestad - Aruba | Willemstad - Curacao | $938 Up To $150 Onboard Credit | View Itinerary | Get FREE Quote | |
100 reviews | 7 Night Southern Caribbean Cruise | Nov 22, 2025 | Royal Caribbean | Serenade of the Seas | Colon | Colon | 7 Nights | Cartagena - Colombia | Colon - Panama | Oranjestad - Aruba | Willemstad - Curacao | $945 Up To $150 Onboard Credit | View Itinerary | Get FREE Quote | |
100 reviews | 7 Night Southern Caribbean Cruise | Nov 29, 2025 | Royal Caribbean | Serenade of the Seas | Colon | Colon | 7 Nights | Cartagena - Colombia | Colon - Panama | Kralendijk - Bonaire | Willemstad - Curacao | $934 Up To $150 Onboard Credit | View Itinerary | Get FREE Quote | |
100 reviews | 6 Night Southern Caribbean Cruise | Dec 06, 2025 | Royal Caribbean | Serenade of the Seas | Colon | Colon | 6 Nights | Cartagena - Colombia | Colon - Panama | Oranjestad - Aruba | Willemstad - Curacao | $939 Up To $150 Onboard Credit | Onboard Credit! | View Itinerary | Get FREE Quote |
16 reviews  | 11 night Costa Rica & Panama Canal (Marvels of Ecuador, Peru, and the Panama Canal (Dec 27 2025)) | Dec 27, 2025 | Windstar | Star Pride | Colon | Lima | 11 Nights | Colón | Guayaquil, Ecuador | Lima, Peru | Manta, Equador | Trujillo, Peru | $8,636 Shipboard Credit Per Person ($150) | Shipboard Credit Per Person ($150) | View Itinerary | Get FREE Quote |
16 reviews | 11 night Costa Rica & Panama Canal (Marvels of Ecuador, Peru, and the Panama Canal (Dec 27 2025)) | Dec 27, 2025 | Windstar | Star Pride | Colon | Lima | 11 Nights | Colón | Guayaquil, Ecuador | Lima, Peru | Manta, Equador | Trujillo, Peru | $5,636 Up To $750 Onboard Credit | View Itinerary | Get FREE Quote | |
100 reviews | 7 Night Southern Caribbean Cruise | Jan 03, 2026 | Royal Caribbean | Serenade of the Seas | Colon | Colon | 7 Nights | Cartagena - Colombia | Colon - Panama | Kralendijk - Bonaire | Oranjestad - Aruba | $918 Up To $150 Onboard Credit | View Itinerary | Get FREE Quote | |
100 reviews | 7 Night Southern Caribbean Cruise | Jan 10, 2026 | Royal Caribbean | Serenade of the Seas | Colon | Colon | 7 Nights | Cartagena - Colombia | Colon - Panama | Oranjestad - Aruba | Willemstad - Curacao | $912 Up To $150 Onboard Credit | View Itinerary | Get FREE Quote | |
3 reviews  | 12 night Caribbean (Colón to Fort-de-France) | Jan 16, 2026 | Ponant | Le Dumont-D Urville | Colon | Fort-De-France | 12 Nights | Cartagena | Colón | Fort-de-France | Les Saintes | Pigeon Island Beach | San Blas Islands | Santa Marta | Soufrière | Union Island | Willemstad | $7,600 Up To $1000 Onboard Credit | View Itinerary | Get FREE Quote | |
100 reviews | 7 Night Southern Caribbean Cruise | Jan 17, 2026 | Royal Caribbean | Serenade of the Seas | Colon | Colon | 7 Nights | Cartagena - Colombia | Colon - Panama | Kralendijk - Bonaire | Oranjestad - Aruba | $935 Up To $150 Onboard Credit | Onboard Credit! | View Itinerary | Get FREE Quote |
16 reviews | 11 night Costa Rica & Panama Canal (Marvels of Ecuador, Peru, and the Panama Canal (Jan 18 2026)) | Jan 18, 2026 | Windstar | Star Pride | Colon | Lima | 11 Nights | Colón | Guayaquil, Ecuador | Lima, Peru | Manta, Equador | Trujillo, Peru | $5,436 Shipboard Credit Per Person ($150) | Shipboard Credit Per Person ($150) | View Itinerary | Get FREE Quote |
100 reviews | 7 Night Southern Caribbean Cruise | Jan 24, 2026 | Royal Caribbean | Serenade of the Seas | Colon | Colon | 7 Nights | Cartagena - Colombia | Colon - Panama | Kralendijk - Bonaire | Oranjestad - Aruba | $788 Up To $150 Onboard Credit | Onboard Credit! | View Itinerary | Get FREE Quote |
100 reviews | 7 Night Southern Caribbean Cruise | Jan 31, 2026 | Royal Caribbean | Serenade of the Seas | Colon | Colon | 7 Nights | Cartagena - Colombia | Colon - Panama | Kralendijk - Bonaire | Oranjestad - Aruba | $885 Up To $150 Onboard Credit | View Itinerary | Get FREE Quote | |
100 reviews | 7 Night Southern Caribbean Cruise | Feb 07, 2026 | Royal Caribbean | Serenade of the Seas | Colon | Colon | 7 Nights | Cartagena - Colombia | Colon - Panama | Kralendijk - Bonaire | Oranjestad - Aruba | $886 Up To $150 Onboard Credit | Onboard Credit! | View Itinerary | Get FREE Quote |
Destinations
- Caribbean - All Cruises (34)
- Caribbean - Western Cruises (32)
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