Lyon straddles the Rhône and Saône Rivers. After Paris, it is considered the country’s most significant cultural center. Amid a cityscape of red-roofed buildings, tree-lined boulevards and riverside promenades, the cobblestone streets of Old Lyon host a rich collection of Renaissance architecture and intimate traboules, unique passageways through buildings that connect adjacent streets, all of it overlooked by the grand basilica atop Fourvière Hill. The city also boasts a wealth of outstanding museums, cultural treasures and excellent Lyonnaise eateries.

Lyon straddles the Rhône and Saône Rivers. After Paris, it is considered the country’s most significant cultural center. Amid a cityscape of red-roofed buildings, tree-lined boulevards and riverside promenades, the cobblestone streets of Old Lyon host a rich collection of Renaissance architecture and intimate traboules, unique passageways through buildings that connect adjacent streets, all of it overlooked by the grand basilica atop Fourvière Hill. The city also boasts a wealth of outstanding museums, cultural treasures and excellent Lyonnaise eateries.

Lyon straddles the Rhône and Saône Rivers. After Paris, it is considered the country’s most significant cultural center. Amid a cityscape of red-roofed buildings, tree-lined boulevards and riverside promenades, the cobblestone streets of Old Lyon host a rich collection of Renaissance architecture and intimate traboules, unique passageways through buildings that connect adjacent streets, all of it overlooked by the grand basilica atop Fourvière Hill. The city also boasts a wealth of outstanding museums, cultural treasures and excellent Lyonnaise eateries.

Situated between France’s Burgundy and Beaujolais regions, Vienne is the gateway to Lyon’s countryside. It is one of the oldest towns in France, with a history that can be traced through its architecture. Among its Roman remains and artifacts, the Roman Temple of Augustus & Livia dates back to the 1st century AD. Its Roman amphitheater, nestled in the hills of Mont Pipet, is one of the best preserved in the nation. Vienne also boasts remarkably preserved medieval buildings and market ruins. Other landmarks include the Abbey of Saint Pierre and the Church of Saint-André-le-Bas.

Tournon lies secluded between the river and the vineyard-blanketed granite slopes that nurture fine vintages. An ancient castle, built snugly into a rock, overlooks the riverside setting. A settlement has perched on this hill since Celtic times, but the stunning views from its overlook have never changed. The name of its neighboring wine-producing region, Tain-l’Hermitage, comes from the hermit who planted vines here after returning from the Crusades. Today, his vines are awash in sunshine and produce a port-like wine and some stellar whites.

In the last days of the Roman Empire, Arles was the capital of Roman Gaul and boasts many Gallo-Roman ruins including Les Arènes; this ancient amphitheater seats 20,000 and is still used today for bullfights and plays. The town has an energetic feel, attracting farmers from the countryside to the frequent and famous Provençal market. It also enjoys a rich artistic heritage; the Mediterranean sunlight here inspired legendary Impressionist Vincent van Gogh to paint a number of works. Many of Arles’s sights are immortalized in his paintings.

Avignon’s narrow streets are lined with churches and remarkable medieval buildings. This “City of Popes” was the papal seat for 70 years during the 14th century after the sitting pope abandoned Rome and fled here. The massive church-fortress Palais des Papes, or Palace of the Popes, was the center of the Christian world during that controversial period. It remains a work of Gothic splendor. Another of Avignon’s notable structures reaches into the Rhône, the ruins of the Pont d’Avignon. The 12th-century bridge, immortalized in folk song and dance, once spanned the river.

Avignon’s narrow streets are lined with churches and remarkable medieval buildings. This “City of Popes” was the papal seat for 70 years during the 14th century after the sitting pope abandoned Rome and fled here. The massive church-fortress Palais des Papes, or Palace of the Popes, was the center of the Christian world during that controversial period. It remains a work of Gothic splendor. Another of Avignon’s notable structures reaches into the Rhône, the ruins of the Pont d’Avignon. The 12th-century bridge, immortalized in folk song and dance, once spanned the river.